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ATI CBC Level 3 Practice Test

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Which medication is used after opioid detox to maintain abstinence?
Correct Answer:
Naltrexone
Explanation:
After detox, the goal is to prevent relapse by blocking the rewarding effects of opioids. Naltrexone does this because it is an opioid receptor antagonist; once receptors are blocked, taking opioids won’t produce euphoria, which helps sustain abstinence. It’s started only after a clear detox has occurred, since giving it while opioids are still in the system can trigger withdrawal. In contrast, methadone and buprenorphine act as opioid agonist or partial agonist therapies that replace the abused opioid with a controlled substance to ease withdrawal and cravings, which supports ongoing opioid use in a controlled way rather than enforcing complete abstinence. Naloxone is used mainly for emergency overdose reversal, not long-term abstinence maintenance.

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