NPLEX II Minor Surgery Practice Test

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Niacinamide is a topical form of which vitamin, and what is a typical concentration for acne use?
Correct Answer:
Vitamin B3; 3-5% concentration
Explanation:
Niacinamide is the topical form of vitamin B3 (nicotinamide). It helps acne by reducing inflammation, moderating sebum production, and strengthening the skin barrier, which can lead to fewer lesions and better tolerance of other acne treatments. For acne, a typical concentration is 3–5%, which balances efficacy with tolerability. Higher concentrations don’t necessarily add benefit and can increase irritation, while lower ones may be less effective. Niacinamide is preferred over niacin because the latter can cause flushing when used topically.

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