Afghanistan Specialization Entry Exam Practice Questions - Afghanistan Medical Specialization (Takhasus) Entry Exam

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A 28-year-old woman presents with symmetrical joint pain and morning stiffness lasting over an hour in her metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints bilaterally for 3 months. Physical examination shows synovitis in 8 joints. Lab tests reveal elevated ESR and positive Anti-Cyclic Citrullinated Peptide (anti-CCP) antibodies. What is the first-line disease-modifying anti-rheumatic drug (DMARD) of choice?

Oral Prednisone 40 mg daily as long-term monotherapy Methotrexate orally once weekly along with Folic acid supplementation Infliximab monotherapy administered intravenously every 2 weeks High-dose Ibuprofen 800 mg three times daily

Correct Answer:

Methotrexate orally once weekly along with Folic acid supplementation

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