AQA A Level Economics Practice Exam

Which of the following is true regarding the pharmacological properties of buprenorphine?

It is a full mu-opioid receptor agonist. It has low affinity for the mu-opioid receptor. It is a partial mu-opioid receptor agonist with high affinity. It has a very short half-life requiring multiple times daily dosing for withdrawal prevention.

Correct Answer:

It is a partial mu-opioid receptor agonist with high affinity.

Explanation:

Buprenorphine is a partial mu-opioid receptor agonist. It binds very tightly (high affinity) to the receptor but only partially activates it (low intrinsic activity), which creates a ceiling effect on respiratory depression and euphoria.

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