Genetics And Molecular Biology Practice Exam

In DNA, which base pairs with Guanine?

Cytosine Adenine Thymine Uracil

Correct Answer:

Cytosine

Explanation:

Base pairing in DNA is based on complementary geometry and hydrogen bonding. Guanine pairs with Cytosine because they form three hydrogen bonds and fit together as a purine-pyrimidine pair, helping maintain the consistent width of the double helix. This differs from Adenine, which pairs with Thymine through two hydrogen bonds, and Uracil, which pairs with Adenine in RNA. So, Guanine's partner in DNA is Cytosine.

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