ENADE Ciências Biológicas Practice Questions - ENADE Ciências Biológicas - Bacharelado And Licenciatura Exam

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In animal epithelial cells, the apical uptake of D-glucose against its concentration gradient is coupled with the influx of sodium ions via the SGLT1 symporter. What mechanism provides the fundamental driving force that sustains this secondary active transport?

Direct enzymatic hydrolysis of cytosolic ATP by the catalytic nucleotide-binding domain of the SGLT1 symporter protein itself. The electrochemical Na+ gradient maintained across the basolateral membrane by primary active transport via the Na+/K+ ATPase pump. Passive facilitated diffusion of K+ out of the cell through apical voltage-gated potassium channels down its chemical gradient. Generation of an alkaline intracellular pH gradient driven by mitochondrial vacuolar-type H+-ATPases.

Correct Answer:

The electrochemical Na+ gradient maintained across the basolateral membrane by primary active transport via the Na+/K+ ATPase pump.

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