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NPLEX II Pharmacology Practice Test

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Which drug carries a risk of Reye's syndrome in children under 12?
Correct Answer:
Aspirin
Explanation:
Aspirin carries the risk of Reye's syndrome in children, especially those under 12. Reye's syndrome is a rare but serious condition that can occur after a viral illness when aspirin is given, leading to acute brain swelling and liver dysfunction. This association makes aspirin the drug to avoid for fever or viral infections in this age group. Other options listed don’t have this risk profile—acetaminophen is commonly used for pediatric fever and pain, though dosing must be careful, and the antibiotics shown aren’t linked to Reye’s syndrome.

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