Singapore GCE A-Level H3 Biology Practice Questions - Singapore GCE A-Level H3 Biology Examination (SEAB Syllabus 9816) Exam

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How does the tumor suppressor protein p53 arrest the cell cycle at the G1/S transition in response to double-stranded DNA breaks?

By transactivating the transcription of p21 (CDKN1A), which inhibits Cyclin E-CDK2 complexes By directly phosphorylating retinoblastoma protein (Rb) to prevent E2F release By ubiquitinating Cyclin D1 to cause its rapid proteasomal degradation By binding to E2F transcription factors to promote their nuclear export

Correct Answer:

By transactivating the transcription of p21 (CDKN1A), which inhibits Cyclin E-CDK2 complexes

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