Western Governors University (WGU) NURS2508 D236 Pathophysiology Practice Exam

Hemophilia is most commonly observed in males due to the nature of the genetic mutation responsible for the condition. It primarily results from a mutation on the X chromosome. Since males have only one X chromosome (XY), if they inherit the mutated gene, they will express hemophilia because they do not have a second X chromosome that could counteract the defective gene. In contrast, females have two X chromosomes (XX). Even if one of their X chromosomes carries the mutation for hemophilia, the other X chromosome can often compensate, leading to the carrier state rather than the disease itself. Consequently, while females can be carriers of the hemophilia gene and may exhibit mild symptoms if one of their X chromosomes has the mutation, the full-blown expression of hemophilia is much more prevalent in males. Therefore, the majority of individuals affected by hemophilia are male, making this the correct choice.