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Step 3 UWSA Practice Exam

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Hepatocellular carcinoma arises from which liver cell type?
Correct Answer:
Hepatocytes
Explanation:
Hepatocellular carcinoma arises from hepatocytes, the liver’s main parenchymal cells responsible for metabolism and detoxification. Chronic liver injury from hepatitis viruses, alcohol, or fatty liver leads to genetic mutations in hepatocytes and their clonal expansion into cancer. Other liver cell types have different tumor origins: cholangiocytes line the bile ducts and give rise to cholangiocarcinoma; endothelial cells line the blood vessels and can form other vascular tumors; hepatic stellate cells are involved in fibrosis and are not the source of hepatocellular carcinoma. Thus, the cancer originates from hepatocytes.

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