ENADE Ciências Biológicas Practice Questions - ENADE Ciências Biológicas - Bacharelado And Licenciatura Exam

A C-terminal KDEL retrieval signal binds to cytoplasmic importin-alpha receptors, directing the ribosome directly to nuclear pore complexes. A core oligosaccharide is transferred to cytosolic lysine residues by chaperone BiP, triggering passive diffusion through peroxisomal pores. An N-terminal hydrophobic signal sequence emerges from the ribosome, is recognized by the Signal Recognition Particle (SRP), halts translation, and docks onto the SRP receptor at the Sec61 translocon. Clathrin triskelions assemble around the ribosome on the cytosolic face, driving endocytic engulfment into cis-Golgi cisternae.