American Society Of Hematology (ASH) ITE Practice Test

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Compared with controls, the relative risk of thrombosis is approximately 2.8-fold for Protein C, Protein S, or Antithrombin deficiency and about 2-fold for antiphospholipid antibodies (APLA).

Protein C, Protein S, or Antithrombin deficiency carry about 2.8-fold risk; antiphospholipid antibodies carry about 2-fold risk. Protein C, Protein S, or Antithrombin deficiency carry about 5-fold risk; antiphospholipid antibodies carry about 4-fold risk. Protein C/S/AT about 1.5-fold; APLA about 2.5-fold. Protein C/S/AT about 2-fold; APLA about 2.8-fold.

Correct Answer:

Protein C, Protein S, or Antithrombin deficiency carry about 2.8-fold risk; antiphospholipid antibodies carry about 2-fold risk.

Explanation:

The key idea is comparing how much each thrombotic risk factor raises the chance of a clot relative to people without the factor. Inherited deficiencies of Protein C, Protein S, or Antithrombin impair natural anticoagulation and raise thrombosis risk to roughly 2.8 times higher than controls. Antiphospholipid antibodies (APLA) also increase risk but to a lesser extent, about 2 times higher. The option that states about 2.8-fold for the deficiencies and about 2-fold for APLA best matches these approximate figures. The other choices propose numbers that are either too high, too low, or swapped, making them less consistent with the given data.

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