CPM DPM Part 1 Practice Questions - Certificate In Pharmaceutical Medicine Exam

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An oral investigational drug undergoes extensive hepatic first-pass metabolism. What effect does this primarily have on the drug's pharmacokinetic profile?

It significantly reduces systemic oral bioavailability (F). It prolongs the terminal elimination half-life (t1/2). It increases the steady-state volume of distribution (Vd). It decreases hepatic clearance (CLhep).

Correct Answer:

It significantly reduces systemic oral bioavailability (F).

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