Título De Especialista Em Alergia E Imunologia Practice Questions - Exame Para Concessão Do Título De Especialista Em Alergia E Imunologia - ASBAI AMB Exam

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According to the classical Gell and Coombs classification of hypersensitivity reactions, which mechanism defines a Type I (immediate) hypersensitivity response?

Cross-linking of allergen-specific IgE bound to high-affinity FcεRI receptors on mast cells and basophils, triggering immediate degranulation and mediator release. Complement-mediated lysis and antibody-dependent cellular cytotoxicity (ADCC) directed by IgG or IgM against cell-surface antigens. Deposition of soluble circulating antigen-antibody immune complexes in vascular beds, activating complement and recruiting neutrophils. Sensitized CD4+ and CD8+ T-cell activation and cytokine release mediating delayed-type tissue damage 48 to 72 hours after antigen exposure.

Correct Answer:

Cross-linking of allergen-specific IgE bound to high-affinity FcεRI receptors on mast cells and basophils, triggering immediate degranulation and mediator release.

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