Arab Board Neurosurgery Final Written Practice Questions - Arab Board Neurosurgery Final Written Examination Exam

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According to the 2021 WHO Classification of Tumors of the Central Nervous System, which molecular or histopathological feature is required to diagnose an adult diffuse astrocytoma as a Glioblastoma, IDH-wildtype (CNS WHO Grade 4), even in the absence of microvascular proliferation or necrosis?

EGFR amplification, TERT promoter mutation, or combined +7/-10 chromosome copy number changes Homozygous deletion of CDKN2A/CDKN2B Co-deletion of chromosome arms 1p and 19q with IDH1 R132H mutation BRAF V600E point mutation with H3 K27M alteration

Correct Answer:

EGFR amplification, TERT promoter mutation, or combined +7/-10 chromosome copy number changes

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