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A physician is managing a wound in a patient with poorly controlled diabetes (HbA1c 10.8%). Which mechanism most directly impairs wound healing in this patient?
Elevated IGF-1 promoting scar overgrowth
Impaired neutrophil chemotaxis and phagocytosis
Excess VEGF causing vascular overgrowth
Upregulated matrix metalloproteinases causing keloid
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Correct Answer:
Impaired neutrophil chemotaxis and phagocytosis
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