SPLE (Pharmacist) Practice Questions - Saudi Pharmacist Licensure Examination (SPLE - Pharmacist) (CBT Via Prometric) Exam

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A pharmacist explains to a student that the loop of Henle in the nephron is the primary site responsible for generating the medullary concentration gradient that allows the kidney to produce concentrated urine. Which transporter in the thick ascending limb is the molecular target of loop diuretics such as furosemide?

Na+-K+-2Cl- (NKCC2) cotransporter Na+-Cl- (NCC) cotransporter in the distal convoluted tubule Epithelial sodium channel (ENaC) in the collecting duct Sodium-glucose cotransporter 2 (SGLT2) in the proximal tubule

Correct Answer:

Na+-K+-2Cl- (NKCC2) cotransporter

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