DOH Pharmacist Exam Practice Questions - DOH Abu Dhabi Pharmacist Qualification Exam

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A patient taking simvastatin should be counselled to avoid large quantities of grapefruit juice primarily because grapefruit:

Inhibits intestinal CYP3A4, increasing statin plasma levels and myopathy risk Induces CYP3A4, reducing the cholesterol-lowering effect Chelates the statin in the gut, preventing absorption Increases renal clearance of the statin, reducing efficacy

Correct Answer:

Inhibits intestinal CYP3A4, increasing statin plasma levels and myopathy risk

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