DHA Pharmacist Licensing Exam

A patient taking simvastatin is prescribed clarithromycin for a respiratory infection. What is the primary concern?

Clarithromycin inhibits CYP3A4, dramatically increasing simvastatin levels and the risk of myopathy/rhabdomyolysis No clinically significant interaction exists The combination reduces the efficacy of clarithromycin Simvastatin increases clarithromycin levels

Correct Answer:

Clarithromycin inhibits CYP3A4, dramatically increasing simvastatin levels and the risk of myopathy/rhabdomyolysis

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