SAPC FQP Exam Practice Questions - SAPC Professional Examination For Foreign-Qualified Persons Exam

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When formulating an aqueous oral solution for a poorly water-soluble weak acid drug, raising the pH above the drug's pKa will most likely:

Increase aqueous solubility because more drug exists in the ionised (salt) form Decrease aqueous solubility because the un-ionised form predominates Have no effect on solubility because pH does not influence weak acids Cause precipitation by converting the drug to its free acid

Correct Answer:

Increase aqueous solubility because more drug exists in the ionised (salt) form

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