Pharmacology Practice Test

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A patient is prescribed penicillin for a gram-positive bacterial infection. What is the primary mechanism by which this antibiotic exerts its bactericidal effect?

Inhibition of DNA gyrase, preventing bacterial DNA replication. Binding to the 30S ribosomal subunit to disrupt protein synthesis. Inhibition of transpeptidase, preventing peptidoglycan cell wall cross-linking. Creation of pores in the bacterial cell membrane, causing leakage of intracellular contents.

Correct Answer:

Inhibition of transpeptidase, preventing peptidoglycan cell wall cross-linking.

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