ABPath Molecular Genetic Pathology Practice Questions - American Board Of Pathology Molecular Genetic Pathology Subspecialty Certification Examination Exam

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A pathology resident asks why mitochondrial DNA testing for MELAS (m.3243A>G) requires evaluation of multiple tissue types. Which property of mitochondrial DNA best explains this?

Mitochondrial DNA undergoes Mendelian inheritance Heteroplasmy levels vary between tissues and over time Mitochondrial DNA is identical to nuclear DNA Mitochondrial DNA is not subject to mutation

Correct Answer:

Heteroplasmy levels vary between tissues and over time

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