CPM DPM Part 1 Practice Questions - Certificate In Pharmaceutical Medicine Exam

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A novel small molecule exhibits very high plasma protein binding (99.5%). If displacement occurs due to a co-administered drug, what is the immediate physiological effect on free drug concentration and clearance?

Transient increase in free drug concentration, leading to increased clearance or tissue distribution until a new steady state is reached. Permanent doubling of total steady-state drug concentration and reduced hepatic metabolism. Immediate reduction in volume of distribution due to decreased cellular uptake. Proportional decrease in renal excretion rate regardless of glomerular filtration.

Correct Answer:

Transient increase in free drug concentration, leading to increased clearance or tissue distribution until a new steady state is reached.

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