Título Em Hematologia E Hemoterapia Practice Questions - Título De Especialista Em Hematologia E Hemoterapia (ABHH AMB) Exam

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Hydroxyurea (hidroxiureia) is the cornerstone disease-modifying pharmacotherapy for patients with Sickle Cell Disease (Doença Falciforme). What is the primary molecular and cellular mechanism through which hydroxyurea exerts its main therapeutic benefit in HbSS patients?

Induction of fetal hemoglobin (HbF / Hemoglobina Fetal) synthesis, which inhibits intracellular deoxy-HbS polymerization. Direct covalent binding to the beta-globin chain preventing sickle erythrocyte dehydration. Competitive inhibition of splenic macrophages to prolong red blood cell lifespan. Direct enzymatic cleavage of abnormal alpha-globin tetramers.

Correct Answer:

Induction of fetal hemoglobin (HbF / Hemoglobina Fetal) synthesis, which inhibits intracellular deoxy-HbS polymerization.

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