PPB Pharmacist Pre-registration Exam Practice Questions - Pharmacy And Poisons Board Pharmacist Pre-registration Examination (Stage I And Stage II) Exam

A medicine undergoes extensive first-pass metabolism. What is the most likely effect after oral administration?

No change in plasma concentration Increased oral bioavailability Reduced amount reaching systemic circulation Immediate renal excretion before absorption

Correct Answer:

Reduced amount reaching systemic circulation

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