HKMLE Part I Practice Questions - Licensing Examination Part I - Examination In Professional Knowledge Exam

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A man with known G6PD deficiency develops jaundice and dark urine after taking an oxidant drug. Blood film shows bite cells. What is the main pathophysiology?

Impaired NADPH production causing oxidative red-cell damage Defective alpha-globin chain synthesis Autoantibody-mediated warm haemolysis Mechanical shearing across a prosthetic valve

Correct Answer:

Impaired NADPH production causing oxidative red-cell damage

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