PEBC Evaluating Exam Practice Questions - PEBC Pharmacist Evaluating Examination Exam

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A drug is administered as an oral tablet and the same dose is given intravenously. The ratio of the area under the plasma concentration-time curve (AUC) after oral administration to the AUC after IV administration is 0.40. What does this value represent?

The fraction of drug bound to plasma proteins The first-pass metabolism fraction lost in the gut wall only The relative bioavailability compared to another oral product The absolute bioavailability of the oral product

Correct Answer:

The absolute bioavailability of the oral product

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