ACCNS-AG Adult-Gerontology Acute Care Clinical Nurse Specialist Certification

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A CNS reviewing a patient's medication list notes the patient takes simvastatin 80 mg and has been newly prescribed clarithromycin for H. pylori. What is the critical drug interaction concern?

Clarithromycin reduces simvastatin efficacy by inducing CYP3A4 metabolism Clarithromycin inhibits CYP3A4, dramatically increasing simvastatin levels and risk of rhabdomyolysis The combination increases clarithromycin levels, requiring dose reduction of the antibiotic There is no clinically significant interaction between these two medications

Correct Answer:

Clarithromycin inhibits CYP3A4, dramatically increasing simvastatin levels and risk of rhabdomyolysis

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