Afghanistan Pharmacy Technician Exit Exam Practice Questions - Afghanistan Pharmacy Technician Exit Exam (Institutes Of Health Sciences) Exam

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Co-trimoxazole is a fixed-dose combination of sulfamethoxazole and trimethoprim. Why is this combination therapeutically synergistic and bactericidal rather than bacteriostatic?

Sulfamethoxazole inhibits bacterial cell wall cross-linking while trimethoprim disrupts the cytoplasmic membrane Sulfamethoxazole competitively inhibits dihydropteroate synthase and trimethoprim inhibits dihydrofolate reductase in sequential steps of bacterial folate synthesis Sulfamethoxazole increases bacterial cell permeability allowing higher intracellular accumulation of trimethoprim Trimethoprim inhibits hepatic CYP450 enzymes preventing the metabolic degradation of sulfamethoxazole

Correct Answer:

Sulfamethoxazole competitively inhibits dihydropteroate synthase and trimethoprim inhibits dihydrofolate reductase in sequential steps of bacterial folate synthesis

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