Basic And Clinical Sciences Examination (BCSE)

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A 6-year-old Golden Retriever is presented with lethargy, polyuria, and polydipsia. A complete blood count (CBC) and serum chemistry panel are performed. The CBC is unremarkable. The chemistry panel reveals a blood glucose of 450 mg/dL (normal: 75-120 mg/dL) and elevated liver enzymes. A urinalysis shows 4+ glucosuria and 2+ ketonuria. Which of the following is the most likely pathologic process responsible for these findings?

Immune-mediated destruction of pancreatic beta cells Neoplastic proliferation of adrenal cortical cells Renal tubular insensitivity to antidiuretic hormone Glycogen storage disease in hepatocytes

Correct Answer:

Immune-mediated destruction of pancreatic beta cells

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