Pharmacology Practice Test

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A 68-year-old male with a history of atrial fibrillation, well-controlled on warfarin, is diagnosed with oropharyngeal candidiasis and is prescribed a course of oral fluconazole. What is the most significant potential interaction the pharmacist should be concerned about?

Inhibition of warfarin metabolism, leading to a supratherapeutic INR and increased risk of bleeding. Increased metabolism of warfarin, leading to a subtherapeutic INR and risk of thrombosis. Decreased absorption of fluconazole, leading to antifungal treatment failure. Displacement of warfarin from plasma proteins by fluconazole, causing a transient increase in free drug.

Correct Answer:

Inhibition of warfarin metabolism, leading to a supratherapeutic INR and increased risk of bleeding.

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