COMSAE Comprehensive Osteopathic Medical Self-Assessment Exam

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A 68-year-old female is diagnosed with multiple myeloma. Her initial lab work shows a hemoglobin of 9.2 g/dL, serum creatinine of 2.5 mg/dL, and serum calcium of 12.1 mg/dL. An X-ray reveals multiple lytic lesions in the vertebrae. Which of these findings is NOT part of the classic CRAB criteria for diagnosing symptomatic multiple myeloma?

Hypercalcemia (Calcium > 11 mg/dL) Renal insufficiency (Creatinine > 2 mg/dL) Anemia (Hemoglobin < 10 g/dL) Thrombocytosis (Platelets > 450,000/µL)

Correct Answer:

Thrombocytosis (Platelets > 450,000/µL)

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