Eidgenössisches Examen Humanmedizin Practice Questions - Eidgenössische Prüfung In Humanmedizin Examen Fédéral En Médecine Humaine Exam

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A 52-year-old male presents with a 4-week history of low-grade fever, night sweats, fatigue, and weight loss. On examination, a new 3/6 holosystolic murmur is heard loudest at the cardiac apex. Fundoscopic exam reveals retinal flame hemorrhages with pale centers (Roth spots), and splinter hemorrhages are visible under the fingernails. What is the most crucial initial diagnostic step before initiating antimicrobial therapy?
Correct Answer:
Drawing at least three separate sets of blood cultures from different venipuncture sites spaced at least 30 to 60 minutes apart, followed by prompt transthoracic echocardiography (TTE)

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