Título Em Hematologia E Hemoterapia Practice Questions - Título De Especialista Em Hematologia E Hemoterapia (ABHH AMB) Exam

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A 4-year-old child with homozygous sickle cell disease (HbSS) undergoes routine primary stroke screening with Transcranial Doppler (Doppler Transcraniano - DTC). The examination reveals a time-averaged maximum mean velocity (TAMV) of 215 cm/s in the right middle cerebral artery, confirmed on repeat testing 2 weeks later. According to established guidelines (STOP trial and PCDT MS), what is the appropriate clinical intervention?

Initiation of a chronic red blood cell transfusion program (transfusão crônica regular) targeting HbS < 30%. Observation with repeat Transcranial Doppler in 12 months without therapeutic intervention. Immediate initiation of aspirin 100 mg daily as monotherapy without transfusion. Immediate surgical revascularization (encephaloduroarteriosynangiosis) prior to medical therapy.

Correct Answer:

Initiation of a chronic red blood cell transfusion program (transfusão crônica regular) targeting HbS < 30%.

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