Afghanistan Specialization Entry Exam Practice Questions - Afghanistan Medical Specialization (Takhasus) Entry Exam

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A 48-year-old female presents with fatigue, cold intolerance, constipation, and weight gain over 6 months. Physical examination reveals delayed deep tendon reflex relaxation and a non-tender diffuse thyroid enlargement. Laboratory tests show TSH of 18.5 mIU/L (normal: 0.4-4.0) and Free T4 of 0.4 ng/dL (normal: 0.8-1.8). What is the most specific serum antibody marker to confirm the underlying etiology?

Anti-thyroid peroxidase (anti-TPO) antibodies Thyroid-stimulating immunoglobulin (TSI) Anti-smooth muscle antibodies (ASMA) Anti-double-stranded DNA (anti-dsDNA) antibodies

Correct Answer:

Anti-thyroid peroxidase (anti-TPO) antibodies

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