WAPCP Part I Practice Questions - West African Postgraduate College Of Pharmacists Part I Examination Exam

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A 45-year-old HIV-positive patient is diagnosed with active pulmonary tuberculosis. The patient is already on a first-line antiretroviral therapy (ART) regimen containing Dolutegravir (DTG). What adjustment is required when co-administering Rifampicin and Dolutegravir?

No adjustment is necessary as Rifampicin does not affect Dolutegravir levels Increase Dolutegravir dose to 50 mg twice daily (BID) Discontinue Dolutegravir and switch to Efavirenz 600 mg once daily Substitute Rifampicin with Rifabutin at standard dosing without adjusting Dolutegravir

Correct Answer:

Increase Dolutegravir dose to 50 mg twice daily (BID)

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