Cert Pulmonology(SA) Phys Practice Questions - Sub-specialty Certificate In Pulmonology Of The College Of Physicians Of South Africa Exam

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A 42-year-old woman receiving BPaL for MDR-TB develops symptomatic peripheral neuropathy and hemoglobin drop to 7.8 g/dL at week 9 of therapy. Linezolid dose was initially 600 mg daily. What is the most appropriate management regarding Linezolid?

Permanently discontinue Bedaquiline and continue Linezolid at 600 mg daily with blood transfusion Replace Linezolid with Ethambutol without dose reduction of other components Increase Linezolid dose to 1200 mg daily to shorten total treatment duration Temporarily interrupt Linezolid until toxicity resolves, then resume at 300 mg daily

Correct Answer:

Temporarily interrupt Linezolid until toxicity resolves, then resume at 300 mg daily

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