TEP Pediatria Practice Questions - TEP - Título De Especialista Em Pediatria (Sociedade Brasileira De Pediatria AMB) Exam

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A 36-hour-old full-term infant born to a mother with blood type O Rh-positive presents with jaundice down to the abdomen (Kramer Zone 2-3). The infant's blood type is A Rh-positive, direct Coombs test is positive, and total serum bilirubin (TSB) is 14.5 mg/dL. What is the most likely pathophysiological mechanism?

Immune-mediated ABO hemolytic disease of the newborn with anti-A IgG antibodies crossing the placenta Physiological jaundice of the newborn secondary to hepatic glucuronyl transferase immaturity Breast milk jaundice (Síndrome da icterícia pelo leite materno) due to beta-glucuronidase Biliary atresia causing early conjugated hyperbilirubinemia

Correct Answer:

Immune-mediated ABO hemolytic disease of the newborn with anti-A IgG antibodies crossing the placenta

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