ABIM Hematology Practice Questions - ABIM Hematology Subspecialty Certification Exam

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A 24-year-old of Southeast Asian ancestry has MCV 68 fL, Hgb 11.0 g/dL, normal iron studies, and hemoglobin electrophoresis with HbA 97%, HbA2 2.4%, HbF 0.5%. Which finding would support alpha-thalassemia trait?

Normal HbA2 and normal HbF with persistent microcytosis Elevated HbA2 >3.5% Elevated HbF 20-30% Presence of HbS on electrophoresis

Correct Answer:

Normal HbA2 and normal HbF with persistent microcytosis

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