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Arab Board Pediatrics Final Written Practice Questions - Arab Board Pediatrics Final Written Examination (ABHS) Exam

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A 12-hour-old term infant born to an Rh-negative mother (blood group O negative) presents with rapidly worsening jaundice. Laboratory evaluation reveals infant blood group A positive, total serum bilirubin 240 umol/L (14 mg/dL), hemoglobin 105 g/L, reticulocyte count 12%, and a strongly positive direct antiglobulin (Coombs) test. Despite 4 hours of intensive phototherapy, total bilirubin increases to 350 umol/L (20.5 mg/dL), crossing the exchange transfusion threshold. In addition to preparing for double-volume exchange transfusion, which pharmacological therapy is indicated to reduce the need for exchange?
Correct Answer:
Intravenous immune globulin (IVIG)

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