Arab Board Neurosurgery Final Written Practice Questions - Arab Board Neurosurgery Final Written Examination Exam

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A 38-year-old male undergoes gross total resection of a left frontal lobe mass. Histopathology demonstrates a diffuse glioma with uniform round nuclei and perinuclear halos ('fried-egg' appearance). Molecular analysis reveals an IDH1 R132H mutation and complete 1p/19q co-deletion. What is the definitive diagnosis and therapeutic implication?

Oligodendroglioma, IDH-mutant and 1p/19q-codeleted (WHO Grade 2 or 3); confers marked chemo-radiosensitivity to PCV Astrocytoma, IDH-mutant (WHO Grade 2); resistant to alkylating chemotherapy Glioblastoma, IDH-mutant (WHO Grade 4); requires immediate high-dose re-irradiation Central neurocytoma; requires observation alone with no adjuvant therapy

Correct Answer:

Oligodendroglioma, IDH-mutant and 1p/19q-codeleted (WHO Grade 2 or 3); confers marked chemo-radiosensitivity to PCV

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