Arab Board Dermatology Part 1 Practice Questions - Arab Board Dermatology And Venereology Part 1 Written Examination (ABHS) Exam

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Profilaggrin, stored within keratohyalin granules of the stratum granulosum, is proteolytically processed into functional filaggrin monomers that bundle keratin intermediate filaments. What is the ultimate fate of filaggrin in the upper stratum corneum?

Degradation into hygroscopic amino acids forming natural moisturizing factor (NMF) Covalent incorporation into the desmosomal inner dense plaque Secretion into the intercellular space as a lamellar lipid bilayer Phosphorylation to form tight junction barrier strands

Correct Answer:

Degradation into hygroscopic amino acids forming natural moisturizing factor (NMF)

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