Arab Board Dermatology Final Practice Questions - Arab Board Dermatology And Venereology Final Written Exam (ABHS) Exam

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A 45-year-old woman with chronic plaque psoriasis experiences acute fever, leukocytosis, and the rapid development of generalized erythroderma studded with sheets of tiny, sterile, non-follicular pustules coalescing into 'lakes of pus' after sudden cessation of systemic corticosteroids. What is the definitive mechanism underlying the targeted therapeutic spesolimab in this condition?

Neutralization of soluble and membrane-bound TNF-alpha Selective blockade of the interleukin-17A homodimer Inhibition of the interleukin-36 receptor (IL-36R) Competitive antagonism of Janus kinase 1 (JAK1)

Correct Answer:

Inhibition of the interleukin-36 receptor (IL-36R)

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