Anesthesia Board Practice Questions - Saudi Board Anesthesia Final Written Exam

Which of the following mechanisms best explains the sedative effect of dexmedetomidine?

GABA-A receptor facilitation in the cerebral cortex NMDA receptor antagonism in the hippocampus Agonism of presynaptic alpha-2 adrenoreceptors in the locus coeruleus Antagonism of dopamine D2 receptors in the basal ganglia

Correct Answer:

Agonism of presynaptic alpha-2 adrenoreceptors in the locus coeruleus

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