Advanced Certified Hospice And Palliative Nurse (ACHPN®) Examination

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An ACHPN is caring for a patient receiving high doses of parenteral hydromorphone who develops new-onset myoclonus, allodynia, and delirium. These symptoms worsen despite an increase in the opioid dose for what was perceived as worsening pain. Which of the following is the most likely diagnosis?

Opioid tolerance Disease progression Opioid-induced neurotoxicity (OIN) Serotonin syndrome

Correct Answer:

Opioid-induced neurotoxicity (OIN)

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