ABPath Hematopathology Practice Questions - ABPath Hematopathology Subspecialty Certification Exam

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A 65-year-old man presents with bruising and bleeding. Peripheral smear shows hypergranular promyelocytes with Auer rods (some faggot cells). Cytogenetics show t(15;17)(q24;q21). The most likely diagnosis is:

Acute myeloid leukemia with RUNX1-RUNX1T1 Acute promyelocytic leukemia (APL) with PML-RARA AML with inv(16) Chronic myeloid leukemia

Correct Answer:

Acute promyelocytic leukemia (APL) with PML-RARA

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