AACC Clinical Chemistry Certification Exam

In immunoassay analyzers, what does the term 'hook effect' (or 'high-dose hook effect') refer to?

A mechanical failure in the probe arm A falsely low result caused by an extremely high concentration of analyte saturating both capture and detection antibodies A cross-reactivity between two structurally similar analytes An instrument error during pipetting of calibrators

Correct Answer:

A falsely low result caused by an extremely high concentration of analyte saturating both capture and detection antibodies

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