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A 62-year-old male on 20 mg prednisone daily presents with a 6-week non-healing surgical wound. Which cellular mechanism most explains his impaired healing?
Inhibition of platelet aggregation
Suppression of macrophage and fibroblast activity with reduced collagen synthesis
Direct bacterial cytotoxicity
Increased keratinocyte apoptosis
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Suppression of macrophage and fibroblast activity with reduced collagen synthesis
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