Título Em Hematologia E Hemoterapia Practice Questions - Título De Especialista Em Hematologia E Hemoterapia (ABHH AMB) Exam

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A 58-year-old male with a history of chronic autoimmune gastritis presents with progressive paresthesias in a stocking-glove distribution, loss of proprioception and vibratory sense, and memory lapses. Laboratory studies reveal: Hb 7.2 g/dL, MCV 118 fL, Platelets 95 x 10^9/L, Leukocytes 3.2 x 10^9/L, LDH 1,850 U/L, Indirect Bilirubin 2.1 mg/dL, and hypersegmented neutrophils on peripheral blood smear. Which diagnostic metabolite profile is most specific for cobalamin (Vitamin B12) deficiency over folate deficiency?
Correct Answer:
Elevated serum methylmalonic acid (MMA) and elevated serum homocysteine.

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