Título Em Endocrinologia E Metabologia Practice Questions - TEEM - Título De Especialista Em Endocrinologia E Metabologia (SBEM AMB) Exam

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A 16-year-old adolescent with newly diagnosed type 1 diabetes mellitus (T1DM) was discharged on a total daily insulin dose of 0.6 units/kg/day. Three months later, his mother reports frequent mild hypoglycemic episodes. Over the past 4 weeks, his required total daily insulin dose has dropped to 0.18 units/kg/day while maintaining fasting glucose between 80–115 mg/dL and postprandial glucose < 140 mg/dL. His HbA1c is 5.8%. Diagnostic autoantibody panel was positive for anti-GAD65 and anti-ZnT8. What clinical phenomenon best explains his current status?

Misdiagnosis of T1DM; the patient has Maturity-Onset Diabetes of the Young (MODY 2). Development of adrenal insufficiency (Schmidt syndrome) causing sudden insulin hypersensitivity. Spontaneous permanent remission of autoimmune insulitis with complete beta-cell regeneration. The 'honeymoon period' (fase de lua de mel), characterized by transient endogenous beta-cell recovery following the correction of initial glucotoxicity.

Correct Answer:

The 'honeymoon period' (fase de lua de mel), characterized by transient endogenous beta-cell recovery following the correction of initial glucotoxicity.

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